Fundamental Investigation of Generating Laser-induced Shock Wave for Development of Regenerative Tissue by Shock Wave

Abstract

This paper proposes a culture tissues regeneration system combining culture promotion and capsule destruction by shock wave, and describes the development of the system. In this system, shock wave are applied to microcapsules containing bubbles for DDS to simultaneously stimulate cells and destroy capsules. The capsule have an important role as a medium for cell culture in regenerative medicine. In this study, shock wave is generated in water using short-time laser with femtosecond as the purpose of stimulating cells. Particle motion around the focal point was observed by image processing. And the pressure at the focal area was also obtained by solving motion equation of particle. As a result, the pressure received by the particle at the position of 48.9μm from the focal point was 192Pa, and the pressure in the focal area was predicted to be 0.29MPa.