Application of the Contraction Force Evaluation Technique of Artificial Skeletal Muscle Under an Electrically Stimulated Environment to the Drug Efficacy

Abstract

In our previous study, we succeeded in fabricating artificial skeletal muscles using a device for supporting artificial skeletal muscles, C2C12 cells, which are mouse rhabdomere-derived cell lines, and collagen gel. Furthermore, we have developed a technique to measure the contraction force of the artificial skeletal muscle over time when it is electrically stimulated. In the present study, we utilized the results of our previous studies to quantitatively evaluate the effect of quercetin on the contraction force of artificial skeletal muscles and developed the device as an alternative to animal experiments for the evaluation of drug effects.