Mechanical evaluation of the developed transparent simulated organs

Abstract

Regenerative medicine, in which stem cells are transplanted into the body to repair damaged organs, is attracting attention. Needle-free syringes are useful as devices of stem cell administration. To observe the internal diffusion of a drug solution for the development of a needle-free syringes, it is necessary to develop an artificial organ that mimics a human organ. We have conducted deformation resistance and shear stress measurements on porcine organs with the goal of producing transparent organs with similar mechanical properties. We investigated the relationship between shear stress and changes in the concentrations of gelatin and cross-linking agents in gel, and the relationship between shear stress and composite gels of gelatin and polymers such as hyaluronic acid, dextran, and polyglutamic acid.