Abstract
Cancer is the leading cause of death in Japan, and improvements in cancer treatment technology are needed. The current main treatments, chemotherapy, surgery, and radiotherapy are highly invasive to the body. Hyperthermia is a minimally invasive treatment that takes advantage of the heat-sensitive properties of cancer cells by heating the tumors to kill it. Magnetic nanoparticle （MNPs） mediated magnetic hyperthermia is one of the cancer treatments, particularly for its ability to affect cell death of deep-seated tumors. However, the heat generation characteristics of MNPs and the method of measuring the temperature inside the body have not yet been clarified, so their practical use has not yet been realized. The aim of this research is to control the temperature of magnetic nanoparticles and measure the temperature in the body. To this end, the laser-induced fluorescence （LIF） method was used to assess how the heat generated by MNPs is transferred to the agar phantoms that simulate a living body during the heating experiment.
