Abstract
For a bone regeneration using a biodegradable scaffold, design of its external shape and geometry of porous microstructure is a key issue to control the structural properties of regenerated bone tissue as well as the regeneration process. During and after the regeneration process, in which degradation of the scaffold and formation of the new bone occurs in the same time frame, bone-scaffold system is required to keep and obtain a desired mechanical function such as the stiffness as a structural system. Scaffold need to have porous structure to expect cell ingrowth and migration, and flow transport of nutrient and metabolic materials. In this study, three-dimensional computational simulation method for a bone-scaffold system in the bone tissue regeneration process using a porous scaffold was newly proposed, and the effects of porous scaffold structure on bone tissue regeneration process were discussed.
