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This paper is a study on the optimum design of a palpation sensor for the diagnosis of prostate abnormalities. The palpation sensor is configured as a polyvinylidene fluoride (PVDF) film placed on a sponge rubber base. Thus, the stiffness of the sponge rubber base of the sensor is of great importance for the best discrimination of normality and abnormality. First, the elastic characteristics of real organ tissues, both normal and abnormal, are investigated. Then, FEM analysis is introduced for the optimal design of sensor and the best fit stiffness of the sponge rubber base is determined.