Since lifting is common in daily life and worksite, inappropriate ways of lifting generally cause low back pain. In this paper, the lifting motion with reduced body burden was simulated using three dimensional link model of a whole body. Motion of the model was analyzed using Newton-Euler method. Musculoskeletal model of upper limb was also developed to predict the muscle force by the simulation. Successive Quadratic Programming (SQP) method was used as an optimization tool for the simulation and analysis. The optimized muscle forces were obtained by minimizing the objective function, sum of squares of muscle force.