Human joints are subjected to dynamic or impact loading in life. However, conventional biomechanical research of human joints have been concerned principally to static loading condition. The purpose of this study was to investigate the mechanism of stress evolution through cancellous bone in knee joint. In this study, the human knee joint FE models which were consisted of hexahedoral finite elements were prepared and were applied impact loading. As the result, the number of element by the hexahedral meshing is less than a quarter of that by the tetrahedral one.