The reduction effect on the vibratory stress of the steam turbine blade with the multi-resonance is studied theoretically for the most probable asymmetric spacing vane, in which the vane count of the upper and lower half is slightly different. The method for the predicting the vibratory stress of the blade for the asymmetric spacing vane is proposed. In order to clarify the validity of the asymmetric spacing vane for the steam turbine, the reduction effects on the vibratory stress in case of applying the asymmetric spacing vane to the existing steam turbine stages are evaluated by using the proposed method.