The interaction between two swimming Paramecium Caudatum is investigated experimentally. The motion of cells is restricted between flat plates. We observed avoiding and escape reactions as well as hydrodynamic interactions. The results show that the cell-cell interaction is mainly hydrodynamic and the biological reaction is a minor incident. We also performed numerical simulations by a boundary element method. P. Caudatum is modelled as a squirmer with the surface velocity measured by a PIV technique. Hydrodynamic interactions observed in the experiment agree well with the numerical simulations, so a squirmer model is appropriate for expressing the motion of P. Caudatum.