The paper proposes a method to analyze the wall thickness distribution of a blood vessel based on the uniform strain hypothesis. The wall is assumed to adaptively increase or decrease its thickness if the first principal strain is higher or lower than a threshold. The simulation is performed by interactively repeating the change in the wall thickness and the structural analysis. Analysis on the bifurcation shows that the final distribution of the vessel wall is not necessarily consistent with the strain distribution at the initial geometry. It is determined through the interactive process between changes in the vessel geometry and corresponding variations of the mechanical environments.