In this paper a multiphisics inverse method is proposed for determining the optimum thermal load history of a thick-walled pipe which reduces transient thermal stress under start-up considering the multidisciplinary physics. The multidisciplinary complex problem was decomposed into a heat conduction problem, heat transfer problem, and thermal stress problem. A numerical solution of the temperature distribution of the radial thickness and the thermal hoop stress distribution was obtained by using the finite element method. The maximum inner hoop tensile stress was minimized for the case where inner surface temperature T_S(t) was expressed in terms of the 3rd order polynomial function of time t. From the temperature distributions, the optimum fluid temperature history was obtained for reducing the transient thermal tensile stress.