The mechanism of the growth of cerebral aneurysm has not yet been understood. We focus on biological reactions in addition to purely mechanical process. We propose a simulation model to express the assumption that surface areas of the arterial wall are increased locally where wall shear stress value is much higher. We applied the model to a U-shaped artery with torsion. The resultant shape was consistent with clinical observations. It is concluded that it is necessary to consider biological reactions to understand the growth of the cerebral aneurysm.