1615 Investigation on Quantitatively Assay of Drug Delivery System using 2-Color Low Coherence Interferometer
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Recently, clinical treatments applying drug delivery system (DDS), e.g. Drug Eluting Stent, have been being developed. However, it is quite difficult to in vivo diagnose spatiotemporal distribution of drug infiltration, so the validation study should be too insufficient to progress the DDS development. In this study, we proposed a quantitatively visualizing assay of DDS, namely 2-Color Optical Coherence Dosigraphy (2C-OCD), which was based on optical coherence tomography using two waveband light sources having different optical absorbance of drug. This can simultaneously provide microscale tomographic images of scatterer density and drug concentration. In this paper, 2C-OCD was applied to biomedical tissue administered DDS drug (AlPcS). The aortic vessel of rabbit, which had highcholesterol diet, was used, and absorption distribution was calculated at the area of arterial plaque. Consequently, tissue characterization and drug distribution in biomedical tissue could be detected by 2C-OCD.
