The proceedings of the JSME annual meeting
Online ISSN : 2433-1325
2008.5
Session ID : 3711
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3711 Biosensor by oligopeptide for assisting the brain tumor removal
Akira OKUBOKenji KOBAYSHIKiyoshi NAEMURA
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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract
Brain tumor cells invade normal cells, without boundary. The purpose of research was to develop a new brain tumor sensor-probe. This paper examines the feasibility of an oligopeptide to sense the brain tumors. By Solid-phase synthesis, a 16mer oligopeptide with fluorescent substance was composed. As a result of refinement, and analysis by high-performance liquid chromatography (HPLC) and Liquid Chromatography-Time of Flight/Mass Spectrometry (LC-TOF/MS) were conducted, I confirmed the composition of the 16mer oligopeptide. When the 16mer oligopeptide dripped on a rat and a porcine brain, a bind reaction with receptor was observed by a fluorescent microscope
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© 2008 The Japan Society of Mechanical Engineers
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