Wearing a CRS reduces fatal or severe injuries of children in traffic accidents. However, a lot of children are still injured while wearing a CRS; hence further improvement of CRS crash safety is required. In this research, a load limiter model and an airbag model were attached to a CRS model. Then, the optimization of the CRS model was performed for further improvement of crash safety. The objectives of this optimization were to reduce the injury values for the head and the neck of a 3-year-old FE human model in the CRS. Response surface method was used to improve the efficiency of the optimization. The optimal design was selected and compared with the original design. As a result, this optimization reduced injury indexes of the optimal design compared to the original design. We demonstrated the possibility of improving the crash safety of the CRS.