A constitutive model of cortical bone for representing stiffness and strength anisotropy and asymmetry of tension and compression was applied to a human femur FE model. The femur model was used for prediction of bone fracture patterns under various loadings of tension, compression, torsion, bending, bending/compression, and bending/torsion. Simulation results predicted by using the constitutive model were compared with those predicted by a simplified model with an isotropic elasto-plastic material model. Comparison between the constitutive model and the simplified model demonstrate that the constitutive model well reproduced bone fracture patterns in comparison with the simplified model.