A simple and high performance cooling structure for PDP-sets, "multi-flow structure" was developed using Computational Fluid Dynamics with heat transfer based on Cartesian grid system. In the conventional cooling structure, upward flow induced by natural convection and fans mainly contributes the cooling for PDP-panel and other PCBs. But simulation results indicated that bypass flow between bottom inlet and fans was formed along the back-cover and the bypass flow reduced the mean exit temperature. For the multi-flow structure, bottom and back inlets were reduced, and top and side inlets were added to induce the flow to high temperature regions. Simulation and experiment results showed that cooling performance of multi-flow structure was superior to the conventional structure. The multi-flow structure was applied to 60V-size PDP-sets.