523 Effects of Mechanical Vibration on Neural Stem Cells

Abstract

Neural stem cells have been studied to promote neurogenesis in regenerative therapy. It is important to investigate not only chemical factors but also mechanical factors such as hydrostatic pressure in. In this study, we investigated effects of mechanical vibration on cell proliferation and differentiation by in-vitro cell culture. It is shown that mechanical vibration promotes the ploliferation and its cause is likely the suppression of apoptosis, and that the mechanical vibration at the experimental condition does not affect the differentiation of neural stem cells to nerve cells or glia cells.