Abstract
Transendothelial channels, found in continuous endothelia, are patent pores spanning the endothelial cell body from lumen to ablumen. A recent paper indicates that they can be provided with two stomatal diaphragms. This structure is expected to affect macromolecular exchanges on the basis of size. This study examines intracellular membrane transport by transendothelial channels and the influence of the diaphragm. A system of nonlinear differential equations determining the shape of channels is derived based on variational principle. After a 3-D model of the channel was constructed, CFD software PHOENICS resolves a general balance equation, instead of well-known fluid equations. Then it provides blood flow through the transendothelial channel with or without diaphragm.
