Recently, many diagnosis devices utilizing light scattered by biological tissue or a cell have been developed. Then understanding of characteristics about light propagation and scattering in biological tissue plays an important role. To investigate those in time domain, we applied FDTD, CIP and IDO method to Maxwell's equations and investigated those accuracy. About in uniform medium, it is found that FDTD method excels at calculating only time averaged intensity and CIP method can analyze phase of waveform with high accuracy, and IDO method has highest accuracy among those methods. Finally, In the case that an infinitely long cylinder is existed in analytical area, scattering light is calculated. The results show that IDO method could have a problem depending on relation between physical value and the special derivation value on the boundary between materials.