Abstract
This paper describes a performance evaluation of a developing differential bio-calorimeter for nano-watt level metabolic heat measurement. High sensitivity is necessary for calorimeter to progress the bio-calorimetry. High sensitive calorimeter enables to reduce sample amount, to shorten the measurement time, and to discover new phenomenon. In order to sensitize bio-calorimetry, the differential bio-calorimeter with two MEMS thermopile sensors was developed. As a result, temperature fluctuation applied to the outer box of 0.128mHz decreased 1/500 with a fourfold thermostatic bath. The differential measurement with the thermopile sensors reduced the thermal noise of 0.128mHz by less than 1/4 of that for a single thermopile case.
