Our goal is to develop a measurement device that uses a biomarker to detect the user's urinary state continuously and non-invasively. What the secreted biomarker reflects the urinary state is still unclear part. Hence, we first developed a prototype device to detect changes in the concentration of glucose solution through an enzyme sensor. Our prototype device achieved stable measurement of glucose solution continuously for more than eight hours. In the current report, we demonstrate the results of acute changes in the concentration of glucose solution detected by our prototype device.