J0203-1-2 Tomographically Diagnosing Technique of Early Cancer using Optical Coherence Tomography Applied to DDS

Abstract

The endoscopic Optical Coherence Tomography (OCT) has been developed for 3-dimensional detection of early cancer with microscale. Nevertheless, it is difficult to detect cancerous tissue due to complicated speckle patterns contributed by optical properties of scattering and absorption in OCT images. Previously, we proposed a visualizing technique of drug distribution, namely 2-Color Optical Coherence Dosigraphy (2C-OCD), which was based on 2-Color OCTs having different optical absorbance of DDS drug. In this study, an in vivo tomographically diagnosing technique of early cancer is presented, in which 2C-OCD is applied to cancerous tissue with selective uptake of DDS drug. The feasibility study was demonstrated and investigated, by means of 2C-OCD visualization of the subcutaneous tumor- implanted nude mice with DDS drug AlPcS administered. Consequently, it was confirmed that 2C-OCD could diagnose tumor tissue with sensitivity 82.5% and specificity 78.3%, respectively. Therefore, 2C-OCD can detect DDS drug distribution in cancerous tissue, thus has a promising modality for in vivo tomographically diagnosing technique of early cancer.