Though strength and toughness of zirconia are high, the wear factor of zirconia/zirconia was larger than that of alumina/alumina in the previous study. However it is considered that changing combinations of materials improve wear properties. Therefore we investigated the wear properties of zirconia/alumina combinations for artificial joint, using end-face apparatus. Bovine serum solution was used as lubrication. Contact pressures were 5 MPa and 10 MPa. Sliding velocity was 40 mm/s, and sliding distance was 10 km. In this study, total wear factor of zirconia/alumina was much less than that of zirconia/zirconia.