This paper presents the development concept and new technologies adopted to the vertical machining center "MP-46V" for high-precision parts and dies/molds machining. In this machine, the rotational speed of the spindle and acceleration of feed axes are increased for reducing the machining time. Moreover, in order to minimize "Junction steps" the new spindle with the rotary shaft cooling system and the advanced Thermo-Friendly Concept for the spindle, "TAS-S" are adopted. In addition we introduce sample cases of dies/molds machining with "MP-46V".