21am2-E7 Separation and detection of biosamples using SPR sensor chip integrated with microslit structures

Abstract

Surface plasmon resonance (SPR) sensing is a non-labeling technique that is widely used for detecting biosamples, which is based on the change of the surface characteristics of a sensor chip. We developed a novel SPR sensor chip fabricated with microslit structures that allows on site filtering of particles and simultaneous analyte detection. To test the feasibility, 2 applications were demonstrated in this paper; detection of aggregation/disaggregation of nanoparticles and fast detection of serum proteins from whole blood.