Abstract
Regeneration of neuron cells is expected to be applied for the procedure of dementia. For regeneration of neuron cells, stretch mechanical stimulation by devices using vertically aligned carbon nanotubes (CNTs) was developed and the relationship between the strain distribution and cell growth pattern was investigated. Device was made of PDMS and CNTs and stretched with a tensile machine. PC12 was cultured with 0%, 5%, 20% strain with 0.1Hz. Although some previous studies reported the cytotoxicity of CNTs, that cells adhere and grow on CNTs as well. Therefore, CNTs used in this study were found to have cell culture compatibility. The lengths of nerve processes have no differences between static and stretch culture. But there are some huge nerve processes with stretch culture. So possibility of beneficial was suggested with CNTs and stretch culture.
