The Proceedings of the Symposium on Micro-Nano Science and Technology
Online ISSN : 2432-9495
2019.10
Session ID : 21pm1PN310
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Protein adhesion in acrylic microchannel of implantable artificial kidney
*Takahiro ItoYosohiko KoyaNorihisa Miki
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Abstract

Most of chronic kidney disease patients need to go to hospital three times per week and must receive more than 4 hours of dialysis treatment each time. Therefore, we aim to develop a multi-layered micro dialysis device which is composed of micro titanium channels and nano-porous PES membranes. However, it takes time to process titanium. Therefore, in this study, I made channels with acrylic, which is easier to process than titanium. In addition, we fabricated a device using an acrylic channel and observed the cohesion of protein to the channel surface by flowing human whole blood. From this result, it was confirmed that the acrylic channel is useful for a short period of about one week. It is necessary to process the surface and coat with antithrombotic material for long-term use.

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© 2019 The Japan Society of Mechanical Engineers
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