Flow diverter stent (FD) is one of an efficient medical device or intracranial aneurysm. FD is a cylindrical device woven from metallic wires. It blocks the inflow entering an aneurysm to make blood coagulation in the aneurysm. But the device has a risk of blood coagulation as well in the parent artery attributable to chemical reactions between metal and blood. Therefore, we have developed the optimization program for mesh design of FD with simulated annealing and computational fluid dynamics to improve the treatment effect maintaining low wire density. In this report, we investigate the relationship between hemodynamic parameters and mesh design to determine the objective function for FD optimization.