Abstract
Endothelial cell (EC) monolayer exposed to shear stress by a blood flow in vivo is a principal barrier for macromolecules transport across vascular wall. It is known that shear stress influences physiological and biochemical processes in ECs. Therefore we studied the effect of shear stress on transendothelial transport. Albumin transport across EC monolayer was high in a low shear stress of 1 Pa, and was low in a high shear stress of 4 Pa. Albumin uptake showed a 1.3 folds increase at 1 Pa. The albumin uptake decreased with increasing shear stress, and minimum uptake was quarter of the control value at 6 Pa.
