Abstract
A cerebral aneurysm is circumscribed dilation of an intracranial artery and can be a cause of subarachnoidal hemorrhage which is a fatal disease when the aneurysm is ruptured. Some clinical data have, suggested that the shape of the aneurysm affects the rupture. However, the relationship between the shape and the rupture has not been revealed. In this study, a new mock cerebral circulatory system was developed in order to evaluate the hemodynamics in the aneurysm in vitro. The mock system consists, of a pulsatile circuit which perfuses fluid in a simulated cerebral artery, in which an aneurysm made of silicone was fixed, and a pressure transducer and an electromagnetic flowmeter to measure the pressure and the flow in the aneurysm. As a result, there is an increase in the pressure in the aneurysm accompanied by a corresponding decrease in the inlet diameter of the aneurysm under the condition of a same inner diameter of the aneurysm. In addition, it is necessary to scrutinizingly examine the flow pattern in the aneurysm by flow visualization and numerical analysis.
