Abstract
Patients with severe motor and intellectual disabilities (herein referred to as "SMID") often spend long periods in bed, and have a high risk of developing kidney stones. At this time, among children with SMID who have stayed at this hospital for an extended time, two cases of repeated urinary-tract infection and recognized kidney stones were targeted to consider the efficacy of cranberry juice (hereinafter referred as CBJ), which has been reported as being effective in preventing urinary-tract infection. Regarding treatment method, Cranberry UR50® was administered at room temperature through a gastronomy tube at 15:00 pm every day. As a result, in Case A, kidney stones observed on both sides had completely shrunk and disappeared 15 months after administration started, and in Case B, kidney stones observed on the right side had completely disappeared 7 months after administration started. It was thought that quinic acid, which is contained in large amounts in CBJ, changes into hippuric acid in the body and is released through the urine. As alkaline approaches to normal pH, and calcium phosphate, which is the main component of kidney stones, is released from the body, and it becomes more difficult to form kidney stones. In conclusion, CBJ is indicated to show a some efficacy in improving nephrolithiasis.
