Abstract
Nebulized tobramycin is effective for treating Pseudomonas aeruginosa infection in patients with cystic fibrosis, and Nebulized tobramycin may be effective in neurologically impaired children. We attempted to treat three cases of recurrent Pseudomonas aeruginoa pneumonia with nebulized tobramycin. Case 1 was a girl aged 4 years and 6 months with trisomy 18. She was treated by tracheal resection and occlusion of vocalfold. After nebulized tobramycin treatment, she had no pneumonia. Case 2 had Kugelberg–Welander disease. He was asphyxiated at 21 years old when he had bronchitis. He underwent tracheotomy and tracheal separation, but he had recurrent Pseudomonas pneumonia and sputum spurted from part of the opening of windpipe. Nebulized tobramycin decreased the sputum and prevented him from pneumonia. Case 3 was an extremely low birth weight infant who was bed ridden from the neonatal period. He was 27years old . He had severe scoliosis and recurrent Pseudomonas pneumonia resulted in CO2 narcosis. Tracheotomy was performed and nebulized tobramycin decreased the number of times of pneumonia. Nebulized tobramycin may be useful for treatment of Pseudomonas aeruginosa pneumonia in severely disabled patients.
