CHRONIC INFLUENCES OF TRANSECTION OF EXTRINSIC NE RVESTO DOG'S STOMACH ON THE FLUCTUATION OF INTRAGASTRIC PRESSURE.

Abstract

15 adult dogs fasted over night were used under Ketalar anesthesia. Experi-ment were undertaken during 3 months on 3 groups of animals vagotomized, splanchnicotomized and transected both extrinsic nerves. The intragastric pressure was measured by balloon-strain gauge method. The intragastricpressurewa elevated in a way of filling with 200 ml of Ringer's solution within 1 minute every 2 minutes till a total of 800 ml.
Following results were obtained
1) The intragastric pressure at the initial period of gastric fullness and the average intragastric pressure during 2 minutes after filling of Ringer's solution in 3 groups were maintained in a higher level compared to that of the control dog at every time after operation and every stage of gastric fullness. Their pressure gradients were shown sharp slopes compared to that of the control dogs.
2) The amplitude of the peristaltic movements in 3 groups was larger than that of the control dogs at every time after operation and every stage of gastricfullness.
3) The results in the chronic experiments were almost the same with that in the acute experiments of the present author (Ikeda, 1976 a b).