Abstract
Electromyographic studies on the effect of Pyrodifenium bromide (Padrin) on the motor function of the gastrointestinal tract of the dogs and human beings were carried out.
1) Electromyographically, padrin when administered intravenously in an amount of 0.5mg. per kg. of body weight had a suppressing effect on the motility of the stomach of dogs. The drug also had a marked suppressing effect on the motility of the small intestine with the amount of 0.25mg. per kg. of body weight.
2) The effect lasted from 30 to 45 min. in the small intestine and less than that in the stomach.
3) Anti-peristalsis of the stomach was restored to normo-peristalsis by Padrin.
4) The drug was effective in reducing the pain and other symptoms in 23 cases including patients of gastrointestinal disorders pre- and postoperatively.
5) Two of the 23 cases developed dryness of the mouth that was only minor side effect noted.
6) From the above-mentioned results, this drug proved to be useful clinically with its suppressing effect on the motor function of the gastrointestinal tract.
