Japanese Journal of Smooth Muscle Research
Online ISSN : 1884-8788
Print ISSN : 0374-3527
ISSN-L : 0374-3527
THE EFFECTS OF N-METHYL-HYOSCINE METHYL SULFATE (DD-234 or 1290 CERM) UPON THE GASTROINTESTINAL MOTILITY AND SALIVATION
Takesi HUKUHARASosogu NAKAYAMAHiroyuki FUKUDAToshiaki NEYAKatsuhiko TSUCHIYA
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1970 Volume 6 Issue 4 Pages 263-269

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Abstract
1) The intravenous administration of DD-234 (5-10μg/kg) inhibited the motilities of the stomach and small intestine of dogs, and the drug (20μg/kg) abolished the excitatory effect of vagal stimulation upon the gastric motility. The administration of the drug into the duodenal lumen inhibited also the vagal excitatory effect.
2) In the isolated rectum and small intestine of dogs, the drug depressed the excitatory effect produced by applying acetylcholine, while that caused by administration of his-tamine or BaCl2 was never inhibited.
3) The salivation from the submandibular gland produced by stimulation of chorda tympani was absolished by administration of the drug.
4) It may be concluded from the results described above that the drug has an anticholinergic activity.
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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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