2022 Volume 27 Issue 1 Pages 143-
We retrospectively examined the clinical course of 5 patients with acute encephalopathy with biphasic seizures and late reduced diffusion（AESD）who were hospitalized to our hospital from April 2014 to March 2019. We compared patients with and without intelligence quotient（IQ）decline after encephalopathy. Two patients showed a decline in developmental quotients. In 2 patients with IQ decline, the duration of the first seizure was ≥60 min, and additional anticonvulsant was required for the initial treatment of convulsions. Treatment after the first seizure, interval between the first seizure and second phase and subsequent treatment were not different between the 2 groups. If convulsions persist for ≥60 min or show resistance to the first anticonvulsants, multidisciplinary treatment with close observation of the patient's clinical course should be started at an early phase considering the high risk of sequelae.
