Review/Advances in Neurological Therapeutics (2016). Dementia

Abstract

Dementia affects over 35 million people in the world with a rapidly increasing prevalence. Alzheimer's disease (AD) is the most common form of dementia. No fundamental treatment for AD has been established, and novel therapeutic strategies are under investigation. This progress has led to the development of numerous therapeutic strategies in the clinical testing. Immunotherapy against Aβ has been pursued extensively as a therapeutic approach to Alzheimer's disease, and several other promising trials are currently ongoing. In addition, new therapeutic strategies have been reported in Huntington's disease and frontotemporal dementia. This review overviews recent advances in basic and clinical research in dementia.