Sleep–related breathing disorder in amyotrophic lateral sclerosis and multiple system atrophy

Abstract

I review diagnosis and treatments against sleep–related breathing disorder (SRBD) observed in neuromuscular diseases including amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). SRBD includes sleep apnea syndrome, nocturnal stridor, hypoventilation, and central respiratory disturbance. These conditions cause frequent awakening, nocturnal pollakiuria, morning headache, and hypersomnia. Clinical examination followed in selected patients by nocturnal saturation monitoring and polysomnography is essential for correct diagnosis and treatments.