Electrophysiological assessment and social interaction related to central sensitization

Abstract

Central sensitization (CS) is a unique phenomenon that indicates hypersensitivity of the central nervous system. It has been assumed that this phenomenon based on a dysregulation of sensory signaling and detected in the various pathological conditions, including neuropathic pain, fibromyalgia, migraine, irritable bowel syndrome, temporomandibular disorder, multiple chemical sensitivity and restless regs syndrome.

However, measuring subjective sensory experience is a task fraught with problems. Thus, objective biological markers are essential for precise diagnosis and understanding of pathophysiological mechanisms of CS.

In the symposium, we proposed several methods of objective assessment of CS using electrophysiological assessment such as auditory or somatosensory paired pulse inhibition. We also reported that the research results on the relationship between sensory hypersensitivity and social interaction.