Review/Advances in Neurological Therapeutics (2018). Brain tumor and granulomatous disease

Abstract

The treatment of brain tumors and granulomatous disease in the brain represents a serious unmet medical need in the field of neuro–oncology. Even though many effective compounds have demonstrated success in treating peripheral tumors with targeted agents, one aspect of this lack of success in the brain may be related to poor delivery of otherwise effective compounds. This review discusses some issues that are pertinent to precision medicine for glioma, brain metastases and neurosarcoidosis with some reports published in 2018. In addition, we introduce the promising results in clinical trials of new–targeted immunetherapies for these diseases.