種々の症状を呈する難治性疾患における中枢神経感作の役割の解明とそれによる患者ケアの向上

平田 幸一; 鈴木 圭輔; 春山 康夫; 小橋 元; 佐伯 吉規; 細井 昌子; 福土 審; 柳原 万理子; 井上 雄一; 西原 真理; 西須 大徳; 森岡 周; 西上 智彦; 團野 大介; 竹島 多賀夫; 端詰 勝敬; 橋本 和明

doi:10.15082/jsnt.37.2_166

The explanation of a role of the central sensitization in the refractory disease patients with various type of symptoms and an improvement of the patients care

Koichi Hirata, Keisuke Suzuki, Yasuo Haruyama, Gen Kobashi, Yoshinori Saeki, Masako Hosoi, Shin Fukudo, Mariko Yanagihara, Yuichi Inoue, Makoto Nishihara, Hironori Saisu, Shu Morioka, Tomohiko Nishigami, Daisuke Danno, Takao Takeshima, Masahiro Hashizume, Kazuaki Hashimoto

Author information

Koichi Hirata
Department of Neurology, Dokkyo Medical University
Keisuke Suzuki
Department of Neurology, Dokkyo Medical University
Yasuo Haruyama
Department of Public Health, Dokkyo Medical University School of Medicine
Gen Kobashi
Department of Public Health, Dokkyo Medical University School of Medicine
Yoshinori Saeki
Division of Palliative Therapy, The Cancer Institute Hospital of JFCR
Masako Hosoi
Department of Psychosomatic Medicine and Multidisciplinary Pain Center, Kyushu University Hospital
Shin Fukudo
Department of Behavioral Medicine, Tohoku University Graduate School of Medicine
Mariko Yanagihara
Japan Somnology Center, Institute of Neuropsychiatry ; Department of Somnology, Tokyo Medical University
Yuichi Inoue
Japan Somnology Center, Institute of Neuropsychiatry ; Department of Somnology, Tokyo Medical University
Makoto Nishihara
Multidisciplinary Pain Center, Aichi Medical University
Hironori Saisu
Multidisciplinary Pain Center, Aichi Medical University
Shu Morioka
Graduate School of Health Sciences, Kio University
Tomohiko Nishigami
Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
Daisuke Danno
Tominaga Hospital, Neurology and Headache Center
Takao Takeshima
Tominaga Hospital, Neurology and Headache Center
Masahiro Hashizume
Department of Psychosomatic Medicine, Toho University School of Medicine
Kazuaki Hashimoto
Department of Psychosomatic Medicine, Toho University School of Medicine

Keywords: central sensitization, central sensitization syndrome, refractory disease

JOURNAL FREE ACCESS

2020 Volume 37 Issue 2 Pages 166-179

DOI https://doi.org/10.15082/jsnt.37.2_166

Details

Abstract

We here review epidemiology, basic and clinical perspective, and pathophysiology of central sensitization in refractory diseases and summarize our researches for care of those patients. This review and our researches were supported by Health, Labour and Welfare Sciences Research Grants, the Ministry of Health, Labour and Welfare, Japan. This review consists of study results obtained from each research group. We have shown central sensitization has some important role in various diseases, especially refractory diseases. We hope our cross–sectional study results may help patient care and may in part clarify the role of central sensitization in refractory diseases, which will be the basis for future research.

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