2021 Volume 38 Issue 3 Pages 164-169
We describe here our results of epidemiological survey for fatigue in Japan, and our recent findings found in chronic fatigue syndrome (CFS) patients. In 1999, our epidemiological survey of 3,015 Japanese people revealed that 35.6% of them had chronic fatigue and 16.8% had a deterioration of daily physical activities. Eight people (0.26%) were diagnosed as CFS according to CDC 1994 criteria. Our recent studies revealed that the existence of neuroinflammation in patients with CFS by the positron emission tomography. We also found that CFS patients exhibited significant differences in intermediate metabolite concentrations in the tricarboxylic acid and urea cycles, and that the identification of actin network proteins in circulating extracellular vesicles were useful as the blood biomarkers for CFS.
