Autoantibody–mediated neuropathic pain and immunotherapy

Abstract

Neuropathic pain often impairs quality of life in patients and becomes a global health issue. Recently, interaction between neuropathic pain and autoantibodies have been attracting much attention. Because autoantibody–mediated neuropathic pain is often a good response to immunotherapy, the detection of pain–generating autoantibodies may lead to clinical improvement in patients with intractable neuropathic pain.

In this review, we describe the clinical features of autoantibody–mediated neuropathic pain and novel candidate neuropathic pain–related autoantibodies.