Brain atrophy in multiple sclerosis

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system. The assessment of neurodegeneration in terms of brain atrophy is of high clinical relevance because it has substantial predictive value with respect to long–term physical disability, cognitive decline and disease progression. Here, we discuss several methods to assess the degree of neurodegeneration in MS.