Dementia prevention through food and nutrition : Nakajima study

Abstract

The Nakajima study is a population–based longitudinal cohort study that investigates cognitive decline in older adults. The study was conducted in Nakajima, in Nanao City of Ishikawa Prefecture, Japan. The proportion of the elderly in Nakajima was higher to that of the whole of Japan and would be almost identical with that of the whole of Japan in the future of 30 years later. The total population of the town has been stable for longtime. In this cohort study, we showed that tooth loss–related dietary patterns were associated with a high prevalence of cognitive decline. We also showed that vitamins C and E reduce the risk of cognitive decline in women with ApoE ε4 and men without ApoE ε4, respectively. In addition, green tea consumption was significantly associated with reduced risk of cognitive decline.