Are DLB and PDD on the same spectrum? ―from a neuropathological perspective―

Abstract

Can Parkinson disease with dementia and Lewy body dementia be considered on the same spectrum? From a neuropathological perspective, the common denominator of both diseases is Lewy pathology. When focusing on Lewy pathology, Parkinson disease, PDD, and DLB can be considered to be on the same spectrum, and are sometimes collectively referred to as Lewy body disease. The most common of these pathologies are amyloid pathology and tau pathology, and the degree of complications also influences clinical symptoms. Recent research results have also pointed out the possibility that PD and DLB may have different fiber structures based on ultrastructural studies. More detailed studies are expected in the future.