A Patient with Protein S Deficiency and a Clinical History of Deep Venous Thrombosis who Underwent Removal of an Impacted Mandibular Third Molar: a case report

Abstract

The Japanese show protein S deficiency more frequently than other congenital causes of thrombosis. Protein S deficiency is considered the highest risk factor for venous thromboembolism in Japanese patients. Because any trauma, surgery, or infection can cause thrombosis in patients with protein S deficiency, careful oral surgical treatment is essential. Conversely, with few reports of oral surgical treatment for this disorder, many issues remain unclear. We successfully extracted an impacted mandibular third molar in a young patient with this disorder and a history of deep venous thrombosis. The patient was hospitalized for the extraction, and the procedure was performed with consideration of hemostasis and prevention of thrombosis relapse.