Abstract
Among 321 cases with oral squamous cell carcinoma （OSCC） from 2001 to 2011 in the Department of Oral and Maxillofacial Surgery, Nagasaki University Hospital, 221 cases were treated with curative intent, and local recurrence was observed in 34 （15.4％） patients. The average time to local recurrence after initial treatment was 11.3 months. The 5-year overall survival rate of the patients with local recurrence was 48.7％. In this study, univariate analysis revealed that the prognosis of salvage surgery of local recurrence in OSCC patients might be associated with neoadjuvant chemotherapy （P＜0.01）, recurrence interval （P＜0.05）, recurrence site （P＜0.01）, and postoperative adjuvant therapy （P＜0.01）. Multivariate analysis revealed that the independent prognostic factor of salvage surgery for recurrence in OSCC patients might be recurrence interval （P＜0.05）, and that NAC and recurrence site tended to be poor prognostic factors of salvage surgery, but there was no significant difference, respectively. It was suggested that the first surgery is very important for a good prognosis in OSCC patients.
